Medical Foundations 4
Chapter 33Assessment of Mood and Anxiety
Part 1: Screening for Mood & Anxiety Disorders – Quick Screening Questions Review
- Why Screen? Evidence suggests depression is under-recognized and under-diagnosed in hospital and ambulatory settings.
- Mood disorders are diagnosed based on presence of mood episodes: Depressive, manic, mixed, or hypomanic.
- Integration with Mental Status Exam: During your interview, you may suspect a mood or anxiety disorder – in this case, you should consider replacing “how is your mood?” general question on MSE with focused screening questions. If you get a +ve screen, you should assess the patient’s symptoms focusing on the Mnemonics and DSM-5 Criteria listed in Part 2.
Resources for Learners:
- Medportal eLearning Course Modules (requires Medportal Login): Mood and Anxiety Assessment.
- ADMSEP eModules (requires Medportal Login): Adjustment Disorders; Anxiety Disorders, Bipolar Disorder.
- Archived Lecture: Clinical Skills LGS on Assessment of Mood and Anxiety (requires Medportal Login)
Depressive Disorders
- Normal: Everyone experiences periods of ↓ mood. A major depressive episode (MDE) is severe and persistent.
- Cognitive Distortion: Ruminative negative filter that infiltrates their world view and view of self, and view of future.
- Other DSM-5 Depressive Disorders: Disruptive Mood Dysregulation Disorder (Prominent feature: Temper flare ups with a baseline irritable/angry mood); Premenstrual Dysphoric Disorder; and Substance/Medication-Induced Depressive Disorder
- Modification for Care of Elderly: Consider using Geriatric Depression Scale (15 item) to assess elderly patients presenting with concerns for Depression. Depression can present differently in Elderly (↑ prominence of Sleep/Energy/Psychomotor Changes, ↓ prominence of dysphoria (affect changes); as well as ↑ complaints of anxiety, memory loss, and fatigue1.
Clinical Question 1 – Does this patient have a Clinical Depression? – Screening Questions23
| Screening Questions | Sens. (95% CI) | Spec. (95% CI) | LR+ (95% CI) | LR – (95% CI) |
|---|---|---|---|---|
| 2 Question Approach (Also called the PHQ-2)2: • During the past month, have you often been bothered by feeling down, depressed or hopeless? • During the past month, have you been bothered by little interest or pleasure in doing things? | 0.97 (0.83-0.99) | 0.67 (0.62-0.72) | 2.9 (2.5-3.4) (about +15%) | 0.05 (0.01-0.35) (about −45%) |
| 1 Question Approach3: Have you felt depressed or sad much of the time in the past year? | 0.828 (0.77-0.877) | 0.875 (0.863-0.887) | 6.65 (5.93-7.46) (about +30%) | 0.196 (0.145-0.265) (about −30%) |
Anxiety Disorders4
- Normal: Every person experiences anxiety – only a clinical problem if it interferes with ability to function or quality of life.
- As a clinician, you need to determine the functional impairment associated with these symptoms for the patient.
- Secondary Avoidance and Coping – when is it a problem? Consider their use of proxies and helpers – these proxies do not need to be logically-routed, but rather are what the patient has come to need to be able to cope
- Anxiety and Appointments: Patients may struggle to attend appointments e.g. (needing to complete rituals, fear of having panic attacks, fear of waiting rooms, facing fears) and request support persons attend with them to ↓ anxiety.
- Comorbidity as a rule: Anxiety disorders are often comorbid with other anxiety disorders, and other psychiatric disorders
- Relationship with Depression: Depression can be considered the final common pathway of anxiety disorders – 80% of patients with anxiety disorders during the course of their illness will present with secondary depression.
- Other DSM-5 Anxiety Disorders: Separation Anxiety Disorder; Selective Mutism; Substance/Medication-Induced Anxiety Disorder; Agoraphobia; Social Phobia; Specific Phobia
Quick Screening Questions for Anxiety Disorders4:
GAD
- During the past 4 weeks, have you been bothered by feeling worried, tense or anxious most of the time?
- Are you frequently tense, irritable, and having trouble sleeping?
Social Anxiety Disorder
- Does fear of embarrassment cause you to avoid doing things or speaking to people?
- Do you avoid activities in which you are the center of attention?
- Is being embarrassed or looking stupid among your worst fears?
Panic Disorder
- Do you have sudden episodes/spells/attacks of intense fear or discomfort that are unexpected or out of the blue? → If yes, ask follow-up questions:
- Have you had more than one of these attacks?
- Does the worst part of these attacks usually peak within several minutes?
- Have you ever had one of these attacks and spent the next month or more living in fear of having another attack and worrying about the consequences of the attack?
Specific Phobia
- Are there any specific things (such as heights, animals or closed spaces) that you fear or avoid?
- Do you think that your fear is excessive?
- Do you have any special fears such as flying or spiders?
Compulsive Disorders
- Challenging to treat: Patient may have insight into how you don’t need to do activity, but a state of ↑↑ intensity until you follow through. With respect to OCD, Patients will tend to have OCD 8-10 years before their diagnosis of OCD
- Other DSM-5 Obsessive-Compulsive and Related Disorders: Body Dysmorphic Disorder; Hoarding Disorder; Trichotillomania; Excoriation; Substance/Medication-Induced Obsessive-Compulsive and Related Disorder.
Quick Screening Questions for Compulsive Disorders4:
Obsessive Compulsive Disorder (OCD)
Obsessions:
- Are you bothered by repeated and unwanted thoughts of any of the following types: Thoughts of hurting someone else; Sexual thoughts; Excessive concern about contamination/germs/disease; Preoccupation with doubts (“what if” questions) or an inability to make decisions; Mental rituals (e.g., counting, praying, repeating); Other unwanted intrusive thoughts
- If you answered “YES” to any of the above… Do you have trouble resisting these thoughts, images, or impulses when they come into your mind?
Compulsions:
- Do you feel driven to perform certain actions or habits over and over again, or in a certain way, or until it feels just right? Such as: Washing, cleaning; Checking (e.g., doors, locks, appliances); Ordering/arranging; Repeating (e.g., counting, touching, praying); Hoarding/collecting/saving
- If you answered “YES” to any of the above… Do you have trouble resisting the urge to do these things?
Bipolar Disorders
Quick Screening Questions for Mania:
Mania
- Have there been times lasting at least several days when you feel high, on top of the world, euphoric, or overly cheery?
- Have you had periods when you are more energetic or active than usual?
- Have you ever had a period of a week or so when you felt so happy and energetic that your friends told you that you were talking too fast or that you were behaving differently or strangely?
- Has there been a period when you were so hyper and irritable that you got into arguments with people?
Trauma or Stressor-Related Disorders
- When do you screen during interview? Do NOT ask at end of interview if you don’t have time to follow-up on a +ve screen. Particularly important in PTSD, where your screen may trigger the patient before you can delve into it. You might need 15 minutes to unpack it and may need to book another appointment. Remember – in PTSD, triggering isn’t just a bringing up of memory of the traumatic event, it is reliving the experience.
- Other DSM-5 Trauma and Stressor-Related Disorders: Reactive Attachment Disorder; Disinhibited Social Engagement Disorder; Acute Stress Disorder; Adjustment Disorders
- Note: Trauma-Informed Care is explored in Appendix 1 – Important Patient-Physician Communication Skills – MF1.
Quick Screening Questions for Posttraumatic Stress Disorder4:
Posttraumatic Stress Disorder
- Have you experienced or seen a life-threatening or traumatic event such as a rape, accident, someone badly hurt or killed, assault, natural or man-made disaster, war, or torture? → If yes, then continue:
- Do you re-experience the event in disturbing (upsetting) ways such as dreams, intrusive memories, flashbacks, or physical reactions to situations that remind you of the event?
Part 2: What to do with a Positive Screen: Mnemonics and Screening Instruments
- General Criterion: Must not be better explained by physiological effects of a substance or other medical condition.
- Screening Instruments in Concert with Mnemonics: The mnemonics listed below reflect the diagnostic criteria in DSM-5. The screening instruments often tend to streamline this process, as well as link it with management guidelines.
Major Depressive Disorder (MDD)
M- SIG E CAPS – 5 of 9, one must be ↓ mood or anhedonia
- Mood
- Sleep → Hypersomnia or Insomnia
- Interest → Anhedonia
- Guilt
- Energy → Fatigue
- Concentration
- Appetite → ↑ or ↓
- Psychomotor → Agitation or Slowing
- Suicidal
DSM-5 Correlation Highlights: Must be present nearly every day for a period of at 14 days; Change from baseline (e.g. chronic insomnia or daytime fatigue); Causing significant impairment in social, occupational or other areas of functioning; Must never have had manic or hypomanic episode
Persistent Depressive Disorder (Dysthymia)
HE’S 2 SAD – 3 of 7, one must be ↓ mood
- Hopelessness
- Energy → Low energy or fatigue
- Self Esteem → Low
- 2 years minimum ↓ mood for most of day, more days than not
- Sleep → Hypersomnia or Insomnia
- Appetite → ↑ or ↓
- Decision making or concentration impaired
DSM-5 Correlation Highlights: Depressed mood must be present for most of the day, for more days than not for at least 2 years; No remission → never a 2-month period free of symptoms; Causing significant impairment in social, occupational or other areas of functioning; Must never have had manic or hypomanic episode
Manic Episode (Bipolar Affective Disorder Type 1)
GST PAID (3 of 7, or 4 of 7 if mood is only irritable)
- Grandiosity → Inflated self-esteem
- Sleep Deficit → Decreased need (e.g. rested on 3 hours’ sleep)
- Talkativeness→ more than usual or pressure to keep talking
- Pleasurable activity, painful consequence→Impulsive/foolish/reckless
- Activity ↑ → Goal-directed (social, work, sex) or psychomotor
- Ideas → Flight of ideas
- Distractibility → attention drawn to irrelevant external stimuli
DSM-5 Correlation Highlights: Requires a distinct period of abnormally, persistently ↑, expansive/irritable mood and abnormally/persistently ↑ goal-directed activity or energy, lasting ≥1 week present most of day, nearly every day (or any duration if requiring hospitalization); Episode causes significant impairment in function, or necessitates hospitalization
*Note: To be diagnosed with Bipolar Affective Disorder Type 1, patient must meet criteria for a manic episode, which may have been preceded and may have been followed by a hypomanic or major depressive episode (MDE – follows same M-SIGECAPS as above)
Hypomanic Episode (Bipolar Affective Disorder Type 2)
TAD HIGH
- Talkative
- Attention deficit
- Decreased need for sleep
- High self-esteem/Grandiosity
- Ideas that race
- Goal-directed activity increased
- High-risk activity
DSM-5 Correlation Highlights: Minimum 4 consecutive days of symptoms most of the day, nearly every day; Hospitalization or psychotic features exclude hypomania
*Note: To be diagnosed with Bipolar Affective Disorder Type 2, patient must meet criteria for a current or past hypomanic episode, and must meet criteria for a current or past major depressive episode (MDE – follows same M-SIGECAPS as above)
Generalized Anxiety Disorder
WATCHERS
- Worry → Apprehensive expectation about number of activities
- Anxiety → about a number of activities
- Tension in muscles
- Concentration difficulty → or “mind going blank”
- Hyperarousal (irritability)
- Energy → Easily fatigued
- Restlessness → feeling keyed up or on edge
- Sleep disturbed → falling or staying asleep, or restless unsatisfying
DSM-5 Correlation Highlights: Required excessive Worry and Anxiety that is difficult to control, more days than not for ≥6 months about number of activities, plus 3 of 6 of other items in mnemonic (TCHERS); Anxiety, worry or physical symptoms cause clinically significant impairment in functioning
Panic Disorder
Panic Attacks: STUDENTS FEAR the 3 Cs – 4 of 13
- Sweating
- Trembling (shaking)
- Unsteadiness (dizziness)
- Depersonalization or Derealisation
- Excessive HR, Palpitations
- Nausea
- Tingling
- Shortness of Breath
FEAR: 2 criteria → Losing Control; and Dying
3 C’s: 3 Criteria → Chest Pain, Choking, and Chills
DSM-5 Correlation Highlights: Panic attacks: Intense fear and discomfort that peaks in minutes; Attacks are recurrent with at least 2 unexpected attacks; 1 month + of persistent worry of additional panic attacks, significant maladaptive changes to avoid them (e.g. avoiding exercise or unfamiliar situations)
Post-Traumatic Stress Disorder
TRAUMAS – 6 of 6 criteria
- Traumatic event
- Re-experiencing the traumatic event (nightmares, flashbacks, etc.)
- Avoidance of stimuli associated with traumatic event
- Unable to function – distressing, significant impairment
- Month – lasts >1 month
- Arousal – startle reaction, poor concentration, hypervigilance
- Self – significant alterations in cognitions and mood
DSM-5 Correlation Highlights: Duration of the disturbance is > 1 month
Obsessive Compulsive Disorder (OCD)
TIRED
- Thoughts – obsessions recurrent, persistent, intrusive, unwanted
- Ignore, suppress or neutralize obsessions – e.g. via compulsions
- Repetitive – compulsive behaviours or mental acts
- Excessive – behaviours not realistically connected with what they’re designed to prevent or neutralize
- Distressing – excessive time use (>1 hr/day) or impairment
DSM-5 Correlation Highlights: Presence of Obsessions (thoughts to ignore, suppress or neutralize), Compulsions (repetitive behaviours that are excessive and disconnected with what they’re designed to prevent), or both
Screening Instruments for Depressive Disorders
Clinical Question 2: Does this patient have a Clinical Depression? – Screening Instruments5
| Condition | Screening Test (n= No. of studies) | Summary LR+ (95% CI) | Summary LR- (95% CI) |
|---|---|---|---|
| Major Depressive Disorder | PHQ-9 (n=2) | 4.9-7.3 | 0.02-0.14 |
| HADS (n=2) | 2.9 (2.5-3.5) | 0.25 (0.15-0.41) | |
| PRIME-MD (n=4) | 2.6 (2.1-3.2) | 0.15 (0.08-0.28) | |
| GDS (n=3) | 2.4-4.0 | 0.12-0.32 | |
| WHO-5 (n=1) | 2.2 (2.0-2.4) | 0.01 (0-0.2) | |
| Yale 1 Item (n=1) | 1.8 (1.1-2.8) | 0.56 (0.27-1.14) | |
| Major Depressive Disorder or Dysthymia | PHQ-9 (n=3) | 5.9 (4.2-8.3) | 0.29 (0.23-0.38) |
| HADS (n=1) | 3.2 (2.7-3.9) | 0.25 (0.18-0.37) | |
| WHO-5 (n=2) | 2.4 (2.2-2.7) | 0.11 (0.06-0.19) |
Screening Instruments for Generalized Anxiety Disorder or Panic Disorder
Clinical Question 3: Does this patient have Generalized Anxiety or Panic Disorder? – Screening Instruments6
| Condition | Screening Test (n= No. of studies) | Sens. (95% CI) | Spec. (95% CI) | LR+ (95% CI) | LR- (95% CI) |
|---|---|---|---|---|---|
| Generalized Anxiety Disorder (GAD) | GAD-7 (n=1) | 0.89 (0.82-0.96) | 0.83 (0.80-0.85) | 5.1 (4.3-6.0) (about +30%) | 0.13 (0.07-0.26) (about −30%) |
| ADS-GA (n=1) | 0.39 (0.12-0.65) | 0.88 0.81-0.95) | 3.2 (1.3-8.0) (about +15%) | 0.70 (0.45-1.08) (no change: 95% CI includes 1) | |
| SDDS-PC (n=3) | 0.78 (0.66-0.87) | 0.67 (0.47-0.82) | 2.6 (1.6-4.1) (about +15%) | 0.31 (0.22-0.43) (about −30%) | |
| GAD-Q IV (n=1) | 0.89 (0.77-1.0) | 0.63 (0.51-0.74) | 2.4 (1.7-3.3) (about +15%) | 0.18 (0.1-0.5) (about −30%) | |
| Panic Disorder | PHQ (n=1) | 0.81 (0.68-0.93) | 0.99 (0.98-1.00) | 78 (29-210) (about +45%) | 0.20 (0.11-0.37) (about −30%) |
| SDDS-PC (n=3) | 0.71 (0.60-0.80) | 0.86 (0.77-0.91) | 4.9 (3.0-7.9) (about +15%) | 0.35 (0.25-0.48) (about −30%) | |
| 10-item scale (n=1) | 0.72 (0.56-0.88) | 0.71 (0.60-0.80) | 2.4 (1.7-3.6) (about +15%) | 0.40 (0.22-0.70) (about −30%) | |
| BPDS (n=1) | 0.61 (0.46-0.76) | 0.29 (0.23-0.35) | 0.86 (0.66-1.1) (no change: 95% CI includes 1) | 1.36 (0.88-2.08) (no change: 95% CI includes 1) | |
| GAD or Panic Disorder | BAI-PC (n=1) | 0.85 (0.65-1.00) | 0.81 (0.67-0.92) | 4.6 (2.3-8.9) (about +15%) | 0.19 (0.05-0.68) (about −30%) |
| PRIME-MD (n=1) | 0.93 (0.88-0.99) | 0.53 (0.48-0.58) | 2.0 (1.8-2.3) (about +15%) | 0.12 (0.05-0.29) (about −30%) |
Clinical Question 4: Does this patient have Post-Traumatic Stress Disorder? – Screening Instruments7
| Condition | Screening Test | Threshold | Sens. (95% CI) | Spec. (95% CI) | LR+ (95% CI) | LR- (95% CI) |
|---|---|---|---|---|---|---|
| PTSD Instruments | Primary Care PTSD Screen (PC-PTSD) | ≥4 | 0.52 (0.40-0.64) | 0.96 (0.91-0.98) | 12.4 (6.7-23.3) (about +45%) | 0.50 (0.38-0.62) (about −15%) |
| ≥3 | 0.69 (0.55-0.81) | 0.92 (0.86-0.95) | 8.5 (5.6-13.0) (about +30%) | 0.34 (0.22-0.48) (about −30%) | ||
| ≥2 | 0.86 (0.79-0.92) | 0.79 (0.74-0.83) | 4.0 (3.3-4.9) (about +15%) | 0.17 (0.11-0.26) (about −30%) | ||
| PTSD Checklist | 45-50 | 0.53 (0.37-0.68) | 0.94 (0.91-0.97) | 9.4 (4.3-19.3) (about +30%) | 0.50 (0.33-0.69) (about −15%) | |
| 38-44 | 0.70 (0.64-0.77) | 0.90 (0.84-0.93) | 6.8 (4.7-9.9) (about +30%) | 0.33 (0.27-0.40) (about −30%) | ||
| 30-31 | 0.84 (0.78-0.89) | 0.80 (0.70-0.87) | 4.1 (2.9-6.1) (about +15%) | 0.21 (0.15-0.28) (about −30%) | ||
| Breslau Scale | ≥5 | 0.71-0.76 | 0.88-0.91 | 5.3-5.9 (about +30%) | 0.18-0.33 (about −30%) | |
| Startle, Physiological Arousal, Anger & Numbness | ≥4 | 0.75-0.89 | 0.78-0.79 | 3.4-4.2 (about +15%) | 0.14-0.32 (about −30%) | |
| ≥3 | 0.77-0.96 | 0.73-0.76 | 2.8-4.0 (about +15%) | 0.05-0.32 (about −45%) | ||
| Sing-Item PTSD Screener (SIPS) | Bothered a little | 0.77 (0.54-0.91) | 0.79 (0.73-0.84) | 3.7 (2.6-5.3) (about +15%) | 0.28 (0.12-0.67) (about −30%) | |
| Trauma Screening Questionnaire | ≥6 | 0.95 (0.90-0.97) | 0.26 (0.22-0.30) | 1.3 (1.2-1.4) (about +15%) | 0.20 (0.10-0.41) (about −30%) | |
| Multi-condition or Anxiety Instruments | K6 | ≥ 13 | 0.10-0.26 | 0.98-1.00 | 13.0-Inf. (about +45%) | 0.76-0.90 (about −15%) |
| My Mood Monitor | ≥2 | 0.88 (0.74-0.95) | 0.76 (0.73-0.79) | 3.7 (3.1-4.4) (about +15%) | 0.16 (0.07-0.36) (about −30%) | |
| GAD-7 | ≥8 | 0.76 (0.66-0.84) | 0.75 (0.72-0.78) | 3.0 (2.6-3.6) (about +15%) | 0.32 (0.22-0.47) (about −30%) |
References
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Katzman MA, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014;14(suppl 1):S1. ↩ ↩2 ↩3 ↩4
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